Long-Term Survival of a Patient with Metastatic MSI-H Colorectal Cancer with Immunotherapy Combined with Chemotherapy Treatment: A Case Report and Review of Literature

Zhao X1, Huang X1, Dezhuan Da2 and Hongling Li2*

1The First Clinical Medical College of Gansu University of Traditional Chinese Medicine, China
2Department of Oncology, Gansu People's Hospital, China

^*Correspondance to: Hongling Li 

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Abstract:

Colorectal Cancer (CRC) is one of the most prevalent malignancies worldwide, accounting for a significant number of cancer-related deaths each year. However, therapeutic options for Colorectal Cancer (CRC) patients with defective DNA Mismatch Repair (dMMR)/high microsatellite instability the survival of dMMR/MSI-H CRC patients. To date, there are no case reports on the use of immunotherapy in combination with chemotherapy for the treatment of dMMR/MSI-H metastatic Colorectal Cancer (mCRC). Here, we report a unique case of a patient with advanced metastatic dMMR/MSI-H colon cancer showing MLH1(+); 2. MSH2(-); MSH6(-); PMS2(+) on colon biopsy demonstrating long-term stable survival under the treatment protocol of Immunotherapy combined with chemotherapy.

Keywords:

Colon cancer; Stage IV, High microsatellite instability; Immunotherapy and chemotherapy

Cite the Article:

Zhao X, Huang X, Dezhuan Da, Hongling Li. Long-Term Survival of a Patient with Metastatic MSI-H Colorectal Cancer with Immunotherapy Combined with Chemotherapy Treatment: A Case Report and Review of Literature. Ann Clin Case Rep. 2023; 8: 2482..