Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Palliative Care
  •  Gastric Cancer
  •  Forensic and Legal Medicine
  •  Vascular Medicine
  •  Signs and Symptoms-Clinical Findings
  •  Genetics
  •  Sleep Medicine and Disorders
  •  Renal Disease

Abstract

Citation: Ann Clin Case Rep. 2023;8(1):2460.DOI: 10.25107/2474-1655.2460

Effect of Time of Echo on 1H-Magnetic Resonance Spectroscopy Imaging of Metabolites in Maxillofacial Carcinoma

Wang B1,2#, Shangguan C3#, Liu S4, Wu J5 and Mi J1*

1Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, China 2Department of Radiological Imaging, Ninth Hospital affiliated with Shanghai Jiao Tong University School of Medicine, China 3Department of Oncology, Shanghai Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, China 4Department of Maxillofacial Surgery, Ninth Hospital affiliated with Shanghai Jiao Tong University School of Medicine, China 5Department of Radiological Imaging, Sixth Hospital affiliated with Shanghai Jiao Tong University School of Medicine, China #These authors contributed equally to this work

*Correspondance to: Jun Mi 

 PDF  Full Text Research Article | Open Access

Abstract:

Background: This study aims to evaluate the effect of Time of Echo (TE) on Magnetic Resonance Spectroscopy Imaging (MRSI) of metabolites in maxillofacial carcinoma. Methods: Twenty maxillofacial carcinoma patients and 10 healthy volunteers were recruited to undergo 1.5-Tesla high-resolution routine MRI and multi-voxel MRSI with a TE of 35 ms and 144 ms. An automated MRSI processing protocol calculated the metabolite peak area, which was analyzed to compare the patients and the volunteers. Results: Although proton MRS with a 144 ms TE could detect choline with better sensitivity than MRS with a 35 ms TE, the choline content was lower in patients than that in volunteers, and the sensitivity of MRS with a 35 ms TE to lactate/lipids was significantly higher than that of 144 ms MRS. The detection baseline of MRS was more constant in the 35 ms MRS than in the 144 ms MRS. Regardless of the subtype of maxillofacial carcinoma, the content of lactate/lipid appeared to be increased in the 20 patients (p<0.001) compared to that in the healthy volunteers. One year after treatment, the content of lactate/lipid returned to the baseline level in 8 patients and was reduced in 5 patients. Conclusion: Our data have demonstrated that MRSI with a 35 ms TE better reveals the content of tumor metabolites, specifically lactate/lipid, suggesting that MRSI with a 35 ms TE can be used to monitor specific metabolites for tumor diagnosis and assess therapeutic response.

Keywords:

1H-Magnetic resonance spectroscopy; Metabolites; Time of echo; Maxillofacial carcinoma

Cite the Article:

Wang B, Shangguan C, Liu S, Wu J, Mi J. Effect of Time of Echo on 1H-Magnetic Resonance Spectroscopy Imaging of Metabolites in Maxillofacial Carcinoma. Ann Clin Case Rep. 2023; 8: 2460..

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