Red Meat Allergy and Castleman′s Disease

Mur Gimeno P, Lombardero Vega M, Jiménez Burgos F, Lozano Cejudo C and Sancho Calatrava E

Department of Allergy, Santa Bárbara Hospital, Puertollano, Spain
Alk-Abelló SA R&D Department, Madrid, Spain
Department of Pathological Anatomy, Santa Bárbara Hospital, Puertollano, Spain
Department of Radiology, Santa Bárbara Hospital, Puertollano, Spain
Department of Surgery, Santa Bárbara Hospital, Puertollano, Spain

^*Correspondance to: Mur Gimeno P 

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Abstract:

Background: Anaphylaxis, angioedema or hives have been described after eating red meat. Tick bites are progressively accepted as the sensitizing agent. Castleman’s disease is a lymphoproliferative process with different impacts on long-term outcome depending on its centricity. Hyalomma lusitanicum is the most prevalent tick in Castilla-La Mancha.Methods: Male, 44 years of age, diagnosed with seasonal rhinoconjunctivitis who reported frequent episodes of anaphylaxis in the past six months 4-5 hours after eating meat or offal of lamb. He tolerated beef, pork, venison, wild boar, rabbit and chicken. He acknowledges having been bitten by ticks.Results: SPT against common aeroallergens: positive for grass and olive pollens. SPT with commercial meats and bovine gelatin-derived colloids (Gelafundin®): negative. IDT with red meats and gelatines: positive. Specific IgE (ImmunoCAP Thermofisher) for meats (lamb 1.54 KU/L, pork 0.82 KU/L, veal 4.94 KU/l), anisakis 14.6 KU/L, ascaris 1.47 KU/L and α-gal 38 KU/L. Spirometry: mixed pattern with bronchodilator response. Chest CT: adenopathy of 13 mm in the left axilla. Lymph node biopsy: compatible with unicentric Castleman’s disease, hyaline-vascular type.Conclusion: We describe two unusual processes in the same patient: delayed anaphylaxis after eating lamb, controlled by exclusion diet, and unicentric Castleman’s disease treated with surgical removal of the lymph node. Ticks population in our area differs from ticks in Europe and the north of Europe.

Keywords:

Anaphylaxis; α-galactose; Food allergy; Castleman’s disease; Lymphoproliferative process

Cite the Article:

Mur Gimeno P, Lombardero Vega M, Jim�nez Burgos F, Lozano Cejudo C, Sancho Calatrava E. Red Meat Allergy and Castleman′s Disease. Ann Clin Case Rep. 2017; 2: 1335.