Department of Obstetrics and Gynecology, University of Gondar, EthiopiaFulltext PDF
Primary amenorrhea is failure to menstruate by the age of 16 years irrespective of secondary sexual characteristics. It is mostly caused by premature ovarian failure secondary to gonadal dysgenesis of which Turner syndrome is the commonest. Congenital problems of the reproductive tract especially Müllerian agenesis is another important cause. Isolated congenital absence of the endometrium is a very rare cause of primary amenorrhea with only two case reports so far. Here I present a 25 years old woman who presented with failure to menstruate but had well-developed secondary sexual characteristics and uterus with patent cavity where congenital absence of the endometrium was found as the cause of her amenorrhea. So, in women with primary amenorrhea in the presence of secondary sexual characteristics and uterus, with absence of endometrial stripe on transvaginal sonography and patent uterine cavity on uterine sounding, congenital absence of the endometrium should be entertained as a cause of primary amenorrhea.
Primary amenorrhea; Congenitally absent endometrium; Congenital female reproductive tract anomalies
Ayichew Z. Congenital Absence of the Endometrium: A Rare Cause of Primary Amenorrhea. Ann Clin Case Rep. 2022; 7: 2160..