A Peculiar Case of Large Tubular Adenomatous Colonic Polyps in a Young Male with Hypermobile Ehlers-Danlos Syndrome

Swapnil Surpur*, Pratiksha S. Nathani, Manav Ghaie, Bhavana Mundrathi, Sai Madhav Dongur, Azra Kothavale and Kaumudi Somnay

Department of Internal Medicine, The Wright Center for GME, Scranton, PA, USA Department of Internal Medicine, Maharashtra University of Health Sciences, Nashik, India Internal Medicine, Government Medical College Patiala, Patiala, India 4Osmania Medical College, hyderabad, India Department of Gastroenterology, NewYork-Presbyterian Queens Hospital, New York City, USA

^*Correspondance to: Swapnil Surpur 

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Abstract:

Ehlers-Danlos Syndrome (EDS) is a group of hereditary connective tissue disorders characterized by a range of clinical features, primarily involving joint hypermobility, skin hyperextensibility, and tissue fragility. These conditions are classified into various subtypes, each with distinct clinical profiles-the hypermobile subtype of Ehlers-Danlos Syndrome (hEDS), formerly known as EDS Type III [1]. hEDS primarily affects the musculoskeletal system, causing joint hypermobility, joint dislocations, and chronic musculoskeletal pain. Individuals with hEDS often experience subluxations or dislocations of joints, particularly those of the shoulders, knees, and hips. Skin involvement, marked by skin hyperextensibility and easy bruising, may also be observed in some cases [1]. While the musculoskeletal aspects of hEDS have been well-documented, its systemic manifestations, particularly in the gastrointestinal system, have received increasing attention in recent years. hEDS is diagnosed in patients based on clinical suspicion and family history, as there is no reliable or appreciable genetic etiology to evaluate in most of the patients. The clinical diagnosis of hEDS requires the simultaneous presence of criteria 1, 2, and 3 [1]. It is also necessary to rule out other connective tissue disorders while establishing this clinical diagnosis.

Keywords:

Ehlers-Danlos Syndrome

Cite the Article:

Surpur S, Nathani PS, Ghaie M, Mundrathi B, Dongur SM, Kothavale A, et al. A Peculiar Case of Large Tubular Adenomatous Colonic Polyps in a Young Male with Hypermobile Ehlers- Danlos Syndrome. Ann Clin Case Rep. 2025; 10: 2778..