Helicobacter pylori Negative Autoimmune Atrophic Gastritis and Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Stomach: Case Report and Systematic Review of the Literature

Veronica Iascone1, Elton Dajti1, Lara Mencarini1, Antonietta D’Errico1,2, Claudio Agostinelli1,3, Pier Luigi Zinzani1,4, Marianna Gentilini1,4, Franco Bazzoli1 and Rocco Maurizio Zagari1,5*

1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy 2Pathology Unit, IRCCS – Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy 3Haematopatology Unit, IRCCS – Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy 4Istituto di Ematologia “L. e A. Seragnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy 5Gastroesophageal disease Unit, IRCCS – Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

^*Correspondance to: Rocco Maurizio Zagari 

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Abstract:

Autoimmune atrophic gastritis (AAG) is a chronic inflammation with atrophy of oxyntic mucosa due to anti-parietal cell and/or anti-intrinsic factor antibodies. Autoimmune atrophic gastritis is a preneoplastic condition that predisposes to type I neuroendocrine tumours and gastric adenocarcinoma. Guidelines recommend endoscopic follow-up of patients with AAG for the early diagnosis of gastric malignancies. There is evidence that some autoimmune diseases may predispose to the development of MALT lymphoma. In this study, we reported the first case of Helicobacter (H.) pylori negative AAG who developed a gastric MALT lymphoma. No other cases were identified by a systematic review of the literature.

Keywords:

Autoimmune atrophic gastritis

Cite the Article:

Iascone V, Dajti E, Mencarini L, D’Errico A, Agostinelli C, Zinzani PL, et al. Helicobacter pylori Negative Autoimmune Atrophic Gastritis and Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Stomach: Case Report and Systematic Review of the Literature. Ann Clin Case Rep. 2025; 10: 2747..