Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Nursing
  •  Allergy & Immunology
  •  Orthopedic Surgery
  •  Microbiology
  •  Renal Disease
  •  Cancer Clinic
  •  Neurology
  •  Oncology Cases


Citation: Ann Clin Case Rep. 2022;7(1):2199.DOI: 10.25107/2474-1655.2199

Multisystem Inflammatory Syndrome in Children Following COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report

Jo KJ, Kim T, Lim JK, Kim YA and Park SE*

Department of Pediatrics, Pusan National University Children’s Hospital, Republic of Korea

*Correspondance to: Park SE 

 PDF  Full Text Case Report | Open Access


Although Coronavirus Disease 2019 (COVID-19) vaccines have been associated with a low incidence of Multisystem Inflammatory Syndrome in Children (MIS-C), several MIS-C cases following COVID-19 vaccination have been reported globally. Here, we report a case of persistent fever, mucocutaneous inflammation, and elevated inflammatory markers after COVID-19 vaccination. A previously healthy 13-year-old boy presented with fever and headache for two days. He had received a second dose of COVID-19 vaccine (Pfizer-BioNTech BNT162b2) approximately nine weeks prior. Laboratory tests revealed elevated levels of inflammatory markers and Echocardiography revealed normal ventricular function and a normal coronary artery. He had no history of diagnosis of COVID-19, and the severe acute respiratory syndrome coronavirus-2 reverse transcriptase polymerase chain reaction result was negative. After admission, the patient developed a skin rash, bilateral conjunctival injection, abdominal pain, and hypotension. Based on diagnostic criteria, MIS-C was strongly suspected. We initiated intravenous gamma globulin and methylprednisolone. Following treatment, the symptoms improved, and inflammatory markers decreased. We report the first Korean child who developed MIS-C following COVID-19 vaccination.


Coronavirus Disease 2019 (COVID-19); COVID-19 vaccination; Multisystem inflammatory syndrome; Children

Cite the Article:

Jo KJ, Kim T, Lim JK, Kim YA, Park SE. Multisystem Inflammatory Syndrome in Children Following COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report. Ann Clin Case Rep. 2022; 7: 2199..

Search Our Journal

Journal Indexed In

Articles in PubMed

Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures
 PubMed  PMC  PDF  Full Text
Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and Naturally Occurring Compounds, Part II
 PubMed  PMC  PDF  Full Text
View More...

Articles with Grants

Clinical Course and Virus Shedding of Mild and Moderate COVID-19 in South China: A Retrospective Study
 Abstract  PDF  Full Text
The Role of Continuous Transvaginal Ultrasound Monitoring for Detection of Early Stage Ovarian Serous Carcinoma in Infertile Women: Three Cases with 5-Year Follow Up
 Abstract  PDF  Full Text
View More...