A Rare Case of Fibrolamellar Hepatocellular Carcinoma in a Young Adult: A Case Report and Literature Review

Houhong Wang and Changquan Li

Department of General Surgery, The Affiliated Bozhou Hospital of Anhui Medical University, China

^*Correspondance to: Changquan Li 

 PDF  Full Text Case Report | Open Access

Abstract:

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a distinct histological subtype of hepatocellular carcinoma (HCC), accounting for approximately 1-2% of all HCC cases. It typically affects young individuals without underlying liver disease, presenting unique clinical, histological, and molecular characteristics. This case report describes a 25-year-old female with no significant medical history who presented with abdominal pain and was subsequently diagnosed with FL-HCC. The patient's clinical course, diagnostic workup, treatment approach, and outcome are detailed. Additionally, a comprehensive literature review is provided to highlight the current understanding of FL-HCC, including its epidemiology, pathogenesis, diagnosis, treatment, and prognosis. This case report aims to contribute to the growing body of knowledge on FL-HCC and emphasize the importance of early recognition and appropriate management of this rare tumor.

Keywords:

Fibrolamellar hepatocellular carcinoma; Young adult; Case report; Literature review

Cite the Article:

Wang H, Li C. A Rare Case of Fibrolamellar Hepatocellular Carcinoma in a Young Adult: A Case Report and Literature Review. Ann Clin Case Rep. 2025; 10: 2742..