The Rare Intraductal Tubular Carcinoma of the Pancreas with Invasive Growth outside the Duct Wall: Histopathological Subtype, Tumor Markers Expression, Microsatellite Detection, and Differential Diagnosis

Huimin Zhao and Fangfang Liu*

Departments of Pathology, Peking University People’s Hospital, China

^*Correspondance to: Fangfang Liu 

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Abstract:

Intraductal Tubular Carcinoma (ITC) is a very rare type of tumor with a complex tubular structure in pancreatic intraductal tumors. Till now, a total of 9 articles have been reported in the international literature. However, many surgeons, imaging doctors, and even pathologists are not familiar with this tumor yet. It is not easy to make a correct diagnosis only by imaging, and misdiagnosis easily led to excessive treatment. Here we describe a case of pancreatic intraductal tubular carcinoma at the body and tail. A 77-year-old male was found to have a mass at the body and tail of the pancreas during the physical examination. Abdominal enhanced CT and enhanced MRI considered it might be a malignant tumor that needed to be differentiated from Malignant Intraductal Papillary Neoplasm (IPMN). “Body and tail of pancreas + splenectomy” was performed. The tumor cells were obvious atypia and arranged in a tubular shape with an invasion of the outer wall of the pancreatic duct under the microscope. The histopathological classification is a neonatal subtype. CK7, CK19, CK20, and MUC1 were diffusely expressed in tumor cells. MLH1, PMS2, MSH2 and MSH6 proteins were not missing (pMMR). Through the diagnosis of ITC and differential diagnosis with pancreatic intraductal tubular adenoma, IPMN, intraductal oncocytic papillary neoplasm, and pancreatic acinar cell carcinoma, this article helps to improve the diagnosis level of pathologists and the treatment level of clinicians.

Keywords:

Pancreatic intraductal tubular carcinoma; Pathological diagnosis; Differential diagnosis; Histopathological subtype; Tumor markers expression

Cite the Article:

Zhao H, Liu F. The Rare Intraductal Tubular Carcinoma of the Pancreas with Invasive Growth outside the Duct Wall: Histopathological Subtype, Tumor Markers Expression, Microsatellite Detection, and Differential Diagnosis. Ann Clin Case Rep. 2021; 6: 2033..