Lobular Carcinoma In Situ within Fibroadenoma: A Case Report and Literature Review

Ye D1#, Zhou B2#, Wu L1#, Liu L1, Zhang Z1, Ye M1, Yang Y1, Wei F1, Zhang G1 and Qingwu L1*

1Department of Pathology, Nanchang First Hospital, Jiangxi Province 330008, China
2Department of Pathology, Dean Huaxing Medical Laboratory Co., Ltd, Jiangxi Province 330089, China
#These authors contributed equally to this work

^*Correspondance to: Li Qingwu 

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Abstract:

Breast fibroadenoma is the most common tumor with benign biological behavior in women. However, the imaging and clinical features of carcinoma in situ within a fibroadenoma are often similar to those of a fibroadenoma. This study aimed to report the case of a 38-year-old young woman with a regular painless mass in her right breast for 6 years. This tumor had a clear boundary and was composed of epithelial and mesenchymal cells. Most of the area comprised the so-called fibroadenoma structure, besides swelling and proliferation in a small part of the terminal duct and no expression of E-cadherin protein. The histological morphology and immunohistochemistry confirmed the diagnosis of a fibroadenoma with lobular carcinoma in situ. We need to be careful of malignant transformation within fibroadenomas and improve the understanding of lobular carcinoma in situ within fibroadenoma.

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Cite the Article:

Ye D, Zhou B, Wu L, Liu L, Zhang Z, Ye M, et al. Lobular Carcinoma In Situ within Fibroadenoma: A Case Report and Literature Review. Ann Clin Case Rep. 2022; 7: 2341.