A Rare Case of Primary Cutaneous Apocrine Carcinoma of the Forehead

Chia-I Chen*, Cuo-shiou Liao, Hao Yen, Cheng-Ping Yu

Department of Surgery, Tri-Service General Hospital, Taiwan Department of Surgery, Division of General Surgery, Tri-Service General Hospital, Taiwan Department of Pathology, Tri-Service General Hospital, Taiwan

^*Correspondance to: Chia-I Chen 

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Abstract:

Primary cutaneous apocrine carcinoma (PCAC) rarely occurs on the forehead, and it is easily mistaken for metastatic ductal carcinoma. The pathology of cutaneous apocrine carcinoma usually involves a mixed pattern of tubular and ductal structures containing poorly demarcated margins with cytonuclear pleomorphism, increased mitotic activity, increased tumor necrosis and micropapillary patterns infiltrating the stroma, and the pathological features are difficult to distinguish from those of metastatic ductal carcinoma. This case report describes a rare case of primary cutaneous apocrine carcinoma of the forehead, which was first considered to have originated from the breast. Furthermore, no standard therapy for the treatment of advanced PCAC has been established yet, and treatment depends on the characteristics of the tumor. A selective estrogen receptor modulator may be a suitable treatment for ER(+) and PR(+) PCAC patients.

Keywords:

Primary cutaneous apocrine carcinoma

Cite the Article:

Chia-I Chen, Cuo-shiou Liao, Hao Yen, Cheng-Ping Yu. A Rare Case of Primary Cutaneous Apocrine Carcinoma of the Forehead. Ann Clin Case Rep. 2025; 10: 2731..