Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Forensic and Legal Medicine
  •  Transplantation Medicine
  •  Gastroenterology
  •  Child Birth
  •  Lung Cancer
  •  Internal Medicine
  •  Ophthalmology
  •  Obstetrics and Gynecology


Citation: Ann Clin Case Rep. 2024;9(1):2576.DOI: 10.25107/2474-1655.2576

Pregnancy Outcome Following ICSI of Oocytes with Abnormal Zona Pellucida: Three Case Reports

Hu J, Lu Z*, Lu H, Li Y, Wang A, Zhao L, Ruan H and Zhong J

Reproductive Medical Center, Hainan Women and Children’s Medical Centre, Haikou, China

*Correspondance to: Zhiyong Lu 

 PDF  Full Text Case Series | Open Access


Three couple were classified as unexplained infertility, and treated by the staff of Reproductive Medicine Center of Hainan Women and Children's Medical Center. It was found that conventional IVF fertilization failed due to abnormal zona pellucida of the oocyte. The zona pellucida of this type of oocyte has a ring-shaped burr, with obvious protrusions like antennae. After ICSI treatment, fertilization, good embryo and clinical outcome were obtained. Finally, one case showed no pregnancy and another two patients had positive serum hCG pregnancy on day 12 after embryo transfer of which a patient suffered a medical abortion due to the absence of yolk sac and embryonic bud in fetuses, another patient gave birth to a healthy pair of a boy-girl twin. It is hypothesized that the spinous ring-shaped zona pellucida can lead to IVF fertilization failure and may be the great obstacle to natural pregnancy. However, fertilization and pregnancy can be achieved by changing the fertilization method, using ICSI and laser-assisted-hatching.


Spinous ring-shaped Zona Pellucida; Fertilization Failure; ICSI

Cite the Article:

Hu J, Lu Z, Lu H, Li Y, Wang A, Zhao L, et al. Pregnancy Outcome Following ICSI of Oocytes with Abnormal Zona Pellucida: Three Case Reports. Ann Clin Case Rep. 2024; 9: 2576..

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