Drug Discovery, Drug Interaction, Drug Abuse, Alcohol Abuse: Compressive Review

Saloni1, Lokesh S2, Vishal V2, Deepanshu2, Kaushal A1 and Divy Mohan A3*

1University Institute of Engineering and Technology, Maharshi Dayanand University, India
2Department of Pharmaceutical Sciences, Maharshi Dayanand University, India
3Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, India

^*Correspondance to: Divy Mohan Arora 

 PDF  Full Text Review Article | Open Access

Abstract:

This article gives a general summary of the steps involved in clinical trial stages, medication interactions, and alcohol generation. Target validation, lead compound selection, target identification, and lead optimisation are all steps in the time-consuming and expensive process of drug development. Finding the right target is essential for developing medications that can successfully cure a certain condition. The effectiveness and therapeutic actions of the target are verified by target validation. As a result of their activity against the target, lead compounds are chosen, but more optimisation is required to increase their efficacy and reduce adverse effects. Before moving on to clinical trials, preclinical investigations are then carried out to assess the drug's pharmacokinetics, pharmacodynamics, and toxicological effects. Clinical trials test a medicine on volunteers and are carried out in stages to evaluate its safety, effectiveness, and dose. While Phase 2 and Phase 3 studies evaluate efficacy and long-term effects, Phase 0 and Phase 1 trials concentrate on safety and dosage tolerance. Overall, this information highlights the intricate and thorough nature of drug discovery and development as well as the significance of rigorous preclinical and clinical research to confirm the safety and efficacy of novel medications.

Keywords:

Alcohol abuse; Drug discovery; Drug interaction; Drug abuse; Pharmacokinetics; Pharmacodynamics; Toxicological effects

Cite the Article:

Saloni, Lokesh S, Vishal V, Deepanshu, Kaushal A, Divy Mohan A. Drug Discovery, Drug Interaction, Drug Abuse, Alcohol Abuse: Compressive Review. Ann Clin Case Rep. 2023; 8: 2521..