Prevalence of Autoimmune Disease in Moyamoya Disease Patients in Central Chinese Population

Jianbin C*

Department of Neurosurgery, Tongji Medical College, Huazhong University of Science and Technology, China

^*Correspondance to: Jianbin C 

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Abstract:

Background: The etiology of Moyamoya Disease (MMD) remains to be unclear. An immunogenic role has been hypothesized but not confirmed. We attempted to investigate the clinical features of autoimmune diseases in MMD patients in central China to further understand the pathogenesis of MMD. Methods: Retrospective clinical features analysis of patients with angiographically identified MMD was conducted and compared with the general Chinese population. Results: Type 1 diabetes mellitus (immune-mediated disease) was found in 18 (5.8%) patients, significantly higher comparing with the Chinese general population (P<0.001, 5.8% vs. 1.3%, χ2 test). The prevalence rate of Graves’ disease (20/312) in Central Chinese population was significantly higher than that in Chinese general population (P<0.001, 6.4% vs. 0.34%, χ2 test). The prevalence of autoimmune thyroiditis was not significantly different than in the Chinese general population (P=0.112, 5.5% vs. 1.5%, χ2 test). Overall, autoimmune disease was associated with Moyamoya disease in 68 out of 312 (21.8%). Conclusion: This study suggested that higher prevalence of autoimmune disease in MMD and autoimmune abnormality might associate with MMD, further supported autoimmune component to the pathogenesis of Moyamoya.

Keywords:

Moyamoya disease; Autoimmune disease; Type 1 diabetes mellitus

Cite the Article:

Jianbin C. Prevalence of Autoimmune Disease in Moyamoya Disease Patients in Central Chinese Population. Ann Clin Case Rep. 2023; 8: 2478.