Could High-Sensitivity C-Reactive Protein Considered as a Biomarker for the Detection Metabolic Syndrome in Iranian Girls?

Fazeli M1,2#, Mohammad-Zadeh M3#, Tabatabaeizadeh SA2, Meshkat Z4, Ferns G5, Bahrami-Taghanaki H6* and Ghayour-Mobarhan M7*

1Department of Molecular Medicine and Medical Genetic, School of Medicine, Mashhad University of Medical Sciences, Iran
2Mashhad University of Medical Sciences, Iran
3Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Iran
4Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Iran
5Department of Medical Education, Brighton & Sussex Medical School, UK
6Chinese and Complementary Medicine Research Center, Mashhad University of Medical Sciences, Iran
7Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Iran
#These authors contributed equally to this work

^*Correspondance to: Majid Ghayour-Mobarhan 

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Abstract:

Background: The prevalence of Metabolic Syndrome (MetS) is increasing globally and is associated with an increased risk of Cardiovascular Disease (CVD) and Type 2 Diabetes Mellitus (T2DM). The increased risk of CVD and T2D in an individual with MetS is proposed to be at least partially related to chronic low-grade inflammation that is reflected by increased serum High-sensitivity C-Reactive Protein (Hs-CRP) level. We aimed to investigate the relationship between serum hs-CRP and MetS. Methods: Nine hundred eighty-eight school girls (mean age 14.56 ± 1.53 years) were recruited using random cluster sampling. Demographic information was collected by questionnaire. Biochemical and anthropometric measures were estimated by standard routine procedures. The IDF, NCEPATPIII, and two modified NCEP (Cook and DeFerranti) were used for metabolic syndrome diagnosis. Results and Conclusion: Our findings show that hs-CRP was associated with WC, elevated serum triglyceride and low HDL in adolescent school girls; but the association with serum HDL was weak. We found no correlation between hs-CRP and blood pressure and FBG. For all definitions of MetS, the prevalence of MetS in a high-risk group of hs-CRP (>3 mg/L) was higher than other groups except when using the DeFerrant definition. Logistic regression revealed that the highest and lowest ORs (CI 95%) were in the Cook (1.410 (1.22-1.63)) and DeFerranti (1.228 (1.14-1.43)) definitions of MetS, respectively. The sensitivity and specificity were: 68.29% to 82.61% and 64.68% to 65.90% for serum hs-CRP using the different definitions, respectively. In ROC analysis, the AUC for different definitions varied between 0.649 to 0.788 and serum hs-CRP cutoff value for all definitions was >1.33 mg/L. In conclusion, serum hs-CRP, an inflammatory marker, may be of useful in the diagnosis of MetS in girls; but not reliable.

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Cite the Article:

Fazeli M, Mohammad-Zadeh M, Tabatabaeizadeh SA, Meshkat Z, Ferns G, Bahrami-Taghanaki H, et al. Could High-Sensitivity C-Reactive Protein Considered as a Biomarker for the Detection Metabolic Syndrome in Iranian Girls?. Ann Clin Case Rep. 2023; 8: 2439..