Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Genetics
  •  Depression
  •  Sports Medicine
  •  Urology Cases
  •  Signs and Symptoms-Clinical Findings
  •  Nursing
  •  Biochemistry and Biostatistics
  •  Cancer Clinic


Citation: Ann Clin Case Rep. 2022;7(1):2160.DOI: 10.25107/2474-1655.2160

Congenital Absence of the Endometrium: A Rare Cause of Primary Amenorrhea

Zelalem Ayichew

Department of Obstetrics and Gynecology, University of Gondar, Ethiopia

*Correspondance to: Zelalem Ayichew 

 PDF  Full Text Case Report | Open Access


Primary amenorrhea is failure to menstruate by the age of 16 years irrespective of secondary sexual characteristics. It is mostly caused by premature ovarian failure secondary to gonadal dysgenesis of which Turner syndrome is the commonest. Congenital problems of the reproductive tract especially Müllerian agenesis is another important cause. Isolated congenital absence of the endometrium is a very rare cause of primary amenorrhea with only two case reports so far. Here I present a 25 years old woman who presented with failure to menstruate but had well-developed secondary sexual characteristics and uterus with patent cavity where congenital absence of the endometrium was found as the cause of her amenorrhea. So, in women with primary amenorrhea in the presence of secondary sexual characteristics and uterus, with absence of endometrial stripe on transvaginal sonography and patent uterine cavity on uterine sounding, congenital absence of the endometrium should be entertained as a cause of primary amenorrhea.


Primary amenorrhea; Congenitally absent endometrium; Congenital female reproductive tract anomalies

Cite the Article:

Ayichew Z. Congenital Absence of the Endometrium: A Rare Cause of Primary Amenorrhea. Ann Clin Case Rep. 2022; 7: 2160..

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