A Giant Phyllodes Tumor of the Breast: A Case Report in Pregnancy

Maria Grazia Tortoriello, Rocco Cerra, Maurizio Di Bonito, Gerardo Botti, Fabiola Gilda Cordaro, Emilia Caputo and Raffaele Tortoriello

Department of Senology, Istituto Nazionale Tumori Fondazione G. Pascale, Italy
Anatomia Patologicae Citologica, Istituto Nazionale Tumori Fondazione G. Pascale, Italy
Institute of Genetics and Biophysics–I.G.B., Italy

^*Correspondance to: Raffaele Tortoriello Emilia Caputo 

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Abstract:

Phyllodes Tumors (PTs) of the breast are rare biphasic fibro epithelial tumor. They account for less than 1% of primary breast tumors. They typically grow rapidly and clinically appears as breast lump in woman within a median age of 45 years. PTs are characterized by an enhanced intra canicular structure with leaf-like project ions into dilated lumens. In the 70% of cases, these tumors constitute benign unilateral lesions of the female breast. Less common are the malignant phyllodes, characterized by stromal pleomorphism and over growth, frequent mitosis and infiltrative borders. PTs, rarely, occur in pregnancy. Here, we present a case of 37 years old women with a giant malignant PT in her left breast, with a maximum diameter of about 24 cm, the largest reported in literature. It grew over 7months, during pregnancy. The histological examination of the resected tumor specimen, after its wide excision, revealed predominance of stromal hyper cellularity with a few altered epithelial component and a focal area showing a leaf-like pattern, consisting with a large malignant phyllodes tumor.

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Cite the Article:

Tortoriello MG, Cerra R, Di Bonito M, Botti G, Cordaro FG, Caputo E, et al. A Giant Phyllodes Tumor of the Breast: A Case Report in Pregnancy. Ann Clin Case Rep. 2017; 2: 1311.