Case Report: Pancreatitis Following Acute Overdose of Clozapine and Review of Possible Mechanisms Involved

Dilin Tang, Wui Ling Chan and Dong Haur Phua

Department of Emergency Medicine, Tan Tock Seng Hospital, Singapore

^*Correspondance to: Dilin Tang 

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Abstract:

Acute pancreatitis is a rare complication of clozapine use. While previous case reports have described pancreatitis from long-term use of clozapine, we present a case of pancreatitis from an acute overdose of clozapine in a young male patient. The patient improved with supportive treatment and transferred to a psychiatric institution subsequently. While the pathophysiology of antipsychotic -induced pancreatitis remains unclear, the effect of the drugs on serotonin receptors may be an important factor in the development of this disease.

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Cite the Article:

Tang D, Chan WL, Phua DH. Case Report: Pancreatitis Following Acute Overdose of Clozapine and Review of Possible Mechanisms Involved. Ann Clin Case Rep. 2017; 2: 1241.