Phytotherapy for Post-Mastectomy Neuropathic Pain in Breast Cancer Survivors: Mechanistic Insights and Integrative Clinical Perspectives

Mahalati K*, Collins J and Forman D

Department of Obstetrics and Gynecology, University of Maryland Capital Region Health, USA Department of Neurology Mercy Health- St. Elizabeth Youngstown Hospital (Level 1 Trauma Center), Youngstown, Ohio, USA Department of Plastic surgery, Georgetown University School of Medicine; Department of Plastic and Reconstructive Surgery, John Hopkins University, USA

^*Correspondance to: Mahalati K 

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Abstract:

Chronic neuropathic pain (CNP) after mastectomy remains a challenging and often refractory condition for many breast-cancer survivors, prompting growing interest in supportive therapies beyond standard pharmacologic options. Phytotherapy provides a scientifically grounded adjunct within integrative and quantum medicine, bridging traditional botanical practice with contemporary molecular research. This review summarizes current evidence on the mechanistic and clinical roles of phytotherapeutic agents in post-mastectomy CNP. Botanicals such as Curcuma longa, Zingiber officinale, and Piper nigrum demonstrate broad activity, including modulation of TRP ion channels, suppression of proinflammatory mediators (TNF-α, IL-6, COX-2), activation of the Nrf2/ARE antioxidant pathway, and regulation of neuroimmune and glial processes involved in central sensitization. Comparisons with gabapentinoids and antidepressants suggest potential synergistic or opioid-sparing effects. Safety considerations—such as standardization, bioavailability, and herb–drug interactions— are also reviewed. When used under appropriate clinical supervision, phytotherapy may support improved analgesia, functional recovery, and quality of life for breast-cancer survivors. Continued research, particularly randomized trials and mechanistic studies, remains essential for responsible clinical integration.

Keywords:

Phytotherapy, Integrative medicine, Neuropathic pain, Neuroinflammation

Cite the Article:

Mahalati K, Collins J, Forman D. Phytotherapy for Post-Mastectomy Neuropathic Pain in Breast Cancer Survivors: Mechanistic Insights and Integrative Clinical Perspectives. Ann Clin Case Rep. 2025; 10: 2811..