Diffuse S-100 Positive Skeletal Ewing Sarcoma: A Rare Diagnostic Enigma

Muhammad Areeb Abdullah*, Humera Mahmood, Sajid Mushtaq, Mohammad Faheem and Sana Kamran

Resident Radiation Oncology, Atomic Energy Cancer Hospital, NORI, Islamabad, Pakistan Director and Chief Oncologist, Atomic Energy Cancer Hospital, NORI, Islamabad, Pakistan Consultant Histopathologist, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan Professor Emeritus and Honourary Consultant, Atomic Energy Cancer Hospital, NORI, Islamabad, Pakistan Consultant Oncologist, Atomic Energy Cancer Hospital, NORI, Islamabad, Pakistan

^*Correspondance to: Muhammad Areeb Abdullah 

 PDF  Full Text Case Summary | Open Access

Abstract:

Ewing Sarcoma is a malignancy which presents usually in the 2nd or 3rd decade of life in the axial skeleton. Immunohistochemistry is used to differentiate this diagnosis from other round blue cell tumours such as neuroblastoma, medulloblastoma etc., which show similar morphology on light microscopy. Diffuse S100 staining is not considered to be positive in this malignancy and such an occurrence mandates diagnostic confirmation by genetic tests such as Fluorescent in situ hybridization. Here we present a case of a EWSR1 gene rearrangement proven case of skeletal Ewing Sarcoma with diffuse S100 positivity in a middle-aged female hailing from Northern Pakistan.

Keywords:

Ewing sarcoma

Cite the Article:

Abdullah MA, Mahmood H, Mushtaq S, Faheem M, Kamran S. Diffuse S-100 Positive Skeletal Ewing Sarcoma: A Rare Diagnostic Enigma. Ann Clin Case Rep. 2025; 10: 2797..