Acute Pulmonary Edema Caused by Considering Cross- Hypersensitivity Between Piperacillin-Tazobactam and Imipenem-Cilastatin Sodium: A Case Report

Juan Chen, Huan-Zhe Zhao, Qiu-Ling Chen, Kuan Li and Ling-Ling Peng

Department of Pharmacy, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China

^*Correspondance to: Ling-Ling Peng 

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Abstract:

Recently, we treated a patient with cross-hypersensitivity reactions caused by piperacillintazobactam and imipenem-cilastatin sodium. The patient was a 36-year-old woman complaining of urinary urgency and increased frequency for one week and fever for one day. She was initially diagnosed with urinary tract infection. Following the administration of piperacillin tazobactam, the patient developed high fever, chills, and vomiting. After adjustment to imipenem-cilastatin sodium, the patient developed acute pulmonary edema. We believe that acute pulmonary edema was caused by cross-hypersensitivity to the two β-lactam drugs.

Keywords:

Cross-hypersensitivity reaction; Piperacillin-tazobactam; Imipenem-cilastatin sodium; Acute pulmonary edema

Cite the Article:

Chen J, Zhao H-Z, Chen Q-L, Li K, Peng L-L. Acute Pulmonary Edema Caused by Considering Cross- Hypersensitivity Between Piperacillin- Tazobactam and Imipenem-Cilastatin Sodium: A Case Report. Ann Clin Case Rep. 2025; 10: 2787..