Hepatitis B Virus Infection Related Scleritis and Ovarian Cancer: A Case Report

Yunping Cai, Jinlu Ma, Shuiyang Zhou, Xiaoli Fan, Cui Lu*& and Song Guo Zheng*&

Department of Rheumatology and Immunology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China Department of Hematology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China Department of Chinese Traditional Medicine, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China Department of Immunology, School of Cell and Gene Therapy, Songjiang Hospital and Songjiang Research Institute Affiliated to Shanghai Jiao Tong University School of Medicine, China These authors contributed equally Senior authors contributed equally

^*Correspondance to: Xiaoli Fan and Cui Lu 

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Abstract:

Hepatitis B virus (HBV) infection is a global public health issue that can lead to liver related complications such as abnormal liver function, cirrhosis, and liver cancer. Some patients may also present with extrahepatic manifestations, including polyarteritis nodosa, arthritis, and glomerulonephritis. Eye involvement may also occur, with most cases presenting as dry eye syndrome. However, there are few reports on HBV infection related scleritis. Here, we report a case of recurrent scleritis with joint pain and multiple abnormal immune and tumor indicators. After thorough identification at the time, it was ultimately considered that the primary disease was HBV infection, and symptoms and various indicators were restored only after antiviral treatment. However, follow-up observations revealed that the patient developed ovarian malignant tumors 3 years later. Through this case, we will strengthen our understanding of the multiple clinical manifestations of hepatitis B virus infection and help identify diseases as soon as possible and try to avoid the waste of medical resources, but we need to be alerted to the occurrence mechanism of extrahepatic manifestations of hepatitis B infection and its correlation with the risk of tumor occurrence.

Keywords:

Hepatitis B, Scleritis, Monoclonal gammopathy of undetermined significance, Ovarian cancer

Cite the Article:

Cai Y, Ma J, Zhou S, Fan X, Lu C, Zheng SG. Hepatitis B Virus Infection Related Scleritis and Ovarian Cancer: A Case Report. Ann Clin Case Rep. 2025; 10: 2717..