A Case of Atypical Presentation of Multiple Transient White Spot Syndrome

Zheng Xin Bao, Su Wen Ru, Zhang Qi Jia, Shen JinYan, Li Ming Fang, Xia Yi Dan, Wu Lu Yun, Yang Fan, Song Guo Zheng* and Yong Wang Zhao*

Department of Ophthalmology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Yexie Community Service Centre, Songjiang District, Shanghai, China Shanghai Jiao Tong University School of Medicine Songjiang Research Institute, Shanghai, China #Authors equally Contributed

^*Correspondance to: Yong Wang Zhao and Song Guo Zheng 

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Abstract:

Multiple evanescent white dot syndrome (MEWDS) was firstly proposed by Jampol et al. [1] in 1984 as a new ophthalmic condition, which is a rare ophthalmic condition characterized by transient deep retinal and retinal pigment epithelium (RPE) lesions. It is a rare ophthalmic disease characterized by transient deep retinal and retinal pigment epithelium (RPE) lesions, with acute onset in one eye, but may involve both eyes. The disease occurs in young myopic women aged 9-44 years old [2], with no racial or genetic predisposition, and is self-limiting to a certain extent, starting to recede 1-2 weeks after the onset of the disease and recovering within 3 months. MEWDS has a variety of signs and symptoms, including haziness of vision, aqueous humor, flashing lights, dark shadows in front of the eyes, and loss of central vision, and funduscopic examination reveals multiple white or yellow-white punctate foci, etc., [3]. With the popularization and promotion of modern imaging technology, the diagnosis of typical MEWDS is relatively easy through multimodal imaging, but a small number of atypical MEWDS (especially in early stage or mild cases) does not have significant vision loss, and there are no characteristic white or yellow-white dotted foci in funduscopic examination, which is easy to miss or misdiagnose, and the clinical diagnosis should be highly valued. We found a case of atypical MEWDS with ‘lack of characteristic white dots’, which is reported as follows.

Keywords:

Multiple evanescent white dot syndrome, Retinal pigment epithelium, Optical coherence tomography

Cite the Article:

Bao ZX, Ru SW, Jia ZQ, Yan SJ, Fang LM, Dan XY, et al. A Case of Atypical Presentation of Multiple Transient White Spot Syndrome. Ann Clin Case Rep. 2025; 10: 2716..