Therapeutic Drug Monitoring Guided Polymyxin Treatment in a Rare Case of Lipoid Pneumonia

Mengyao Li, Juan Chen, Phillip J. Bergen, Shunyao Xu, Dongyu Liu, Jian Li and Xueyan Liu

Department of Critical Care Medicine, First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), China Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, China Department of Pharmacy, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), China Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Australia

^*Correspondance to: Xueyan Liu 

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Abstract:

Exogenous lipoid pneumonia caused by diesel siphonage is a rare condition. Here, we report a case of severe pneumonia, septicemia, and sepsis following diesel siphonage. The patient was treated with ventilator support, corticosteroids, extracorporeal membrane oxygenation, therapeutic lung lavage, and antimicrobials. With therapeutic drug monitoring guiding dosage optimization, polymyxin B was used as an essential chemotherapy to successfully treat multi-drug resistant Gram-negative bacterial infections. The patient recovered well following effective clinical interventions. Overall, therapeutic drug monitoring is beneficial for safely optimizing polymyxin B dosing to maximize efficacy and minimize adverse events.

Keywords:

Keywords: Exogenous lipoid pneumonia; Polymyxin B; Therapeutic drug monitoring; Dosage optimization

Cite the Article:

Li M, Chen J, Bergen PJ, Xu S, Liu D, Li J, et al. Therapeutic Drug Monitoring Guided Polymyxin Treatment in a Rare Case of Lipoid Pneumonia. Ann Clin Case Rep. 2024; 9: 2688..