Quetiapine Induced Severe Hypertriglyceridemia and Diabetic Ketoacidosis: A Case Report

Parikh A, Zara A and Hader I

HCA Houston Healthcare Kingwood, USA

^*Correspondance to: Aarohi Parikh 

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Abstract:

Introduction: Second generation antipsychotics antagonize dopamine receptors but also affect other receptors including serotonin, histamine, and muscarinic receptors. They are known to cause disturbances in metabolism, but rarely do they induce severe hypertriglyceridemia. There are only a handful of cases reported where the second-generation antipsychotic, quetiapine, has caused severe hypertriglyceridemia over 2000 mg/dL concurrently with diabetic ketoacidosis. Case Report: We report a case with a middle-aged female taking quetiapine 800 mg/dL at bedtime who developed severe hypertriglyceridemia greater than 2000 mg/dL with diabetic ketoacidosis and was treated with a continuous weight-based insulin infusion. Her recovery was uneventful and she was discharged five days later. Discussion/Conclusion: Quetiapine’s ability to cause severe hypertriglyceridemia is believed to be attached to its ability to cause weight gain and insulin resistance, which allows for diabetic ketoacidosis to occur simultaneously. In rare cases acute pancreatitis can occur, but is often masked in diabetic ketoacidosis due to overlapping symptoms. Mainstay treatment is an insulin infusion, and plasmapheresis can be used if acute pancreatitis occurs. Novel agents are currently underway of trials for reduction of chronic hypertriglyceridemia and some bring promise to new possibilities.

Keywords:

Quetiapine; Severe Hypertriglyceridemia; Diabetic Ketoacidosis

Cite the Article:

Parikh A, Zara A, Hader I. Quetiapine Induced Severe Hypertriglyceridemia and Diabetic Ketoacidosis: A Case Report. Ann Clin Case Rep. 2024; 9: 2664..