Rescue rFVIIa Treatment for Gestational Leukemia with Severe Bleeding Combined with Ineffective Platelet Transfusion: A Case Report and Literature Review

Wenyi G1, Shuli G1, Li Bo1, Junli S2, Zhihong Z3 and Huirui W1*

1Department of Hematology, Luoyang Central Hospital, Zhengzhou University, China
2ICU, Luoyang Central Hospital, Zhengzhou University, China
3Department of Blood transfusion, Luoyang Central Hospital, Zhengzhou University, China

^*Correspondance to: Huirui Wang 

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Abstract:

Background: Severe bleeding is a leading cause of death among acute leukemia patients. For those patients with non-acute promyelocytic leukemia, Platelet Transfusion Refractoriness (PTR) often coincides with thrombocytopenia during the bone marrow suppression phase after chemotherapy, as this period is characterized by a high risk of bleeding in patients. Recombinant activated Factor VII (rFVIIa) has shown good therapeutic efficacy in diseases including hemophilia and thrombocytopenia, but it has not been widely used in patients with malignant hematological diseases. Methods: Here, we describe the case of a patient with gestational leukemia who developed PTR, but whose bleeding systems failed to improve after multiple treatments. This patient subsequently underwent treatment with rFVIIa. Results: Following the administration of rFVIIa, the patient’s bleeding stopped and they did not experience any adverse events. Conclusion: This case demonstrates that rFVIIa holds promise as a potential rescue treatment for use in patients with malignant hematological diseases experiencing severe bleeding accompanied by PTR.

Keywords:

rFVIIa; Malignant hematological diseases; PTR; Bone marrow suppression; Severe bleeding

Cite the Article:

Wenyi G, Shuli G, Li Bo, Junli S, Zhihong Z, Huirui W. Rescue rFVIIa Treatment for Gestational Leukemia with Severe Bleeding Combined with Ineffective Platelet Transfusion: A Case Report and Literature Review. Ann Clin Case Rep. 2024; 9: 2585..