The Changes of von Willebrand Factor and Endocan Concentrations During and After Reversion of Paroxysmal Ventricular Tachycardia

Wang Y1, Feng XK2, Ma GD1, Jin H1, Zhai Z1 and Li C3*

1Department of Cardiovascular Medicine, Tsinghua University YuQuan Hospital, China
2Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, China
3Beijing Friendship Hospital, Capital Medical University, China

^*Correspondance to: Chunsheng Li 

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Abstract:

Objective: To observe the risk factors of paroxysmal supraventricular tachycardia is important, in order to evaluate trigger conditions and their control. To observe the changes of von Willebrand Factor (vWF) and Endocan concentrations during and after reversion of Paroxysmal Ventricular Tachycardia (PSVT), and to explore the relationships between vWF Endocan and PSVT. Methods: 100 adults with PSVT who were admitted to the rescue room of Beijing Chao-Yang Hospital, Capital Medical University from November 2016 to October 2019 were taken as a study group. The group was evaluated the risk factors of supraventricular tachycardia. It was further divided into three subgroups (32, 32 and 36 for each) based on the disease onset time (T ≤ 3 h, 3 h 24 h). In the meantime, 35 patients with sinus rhythm were also taken as study group for control analysis. All patients vWF and Endocan levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) for statistical analysis. Results: 1. Alcohol intake, smoking, and stress were risk factors for paroxysmal supraventricular tachycardia. 2. The levels of vWF and Endocan in PSVT group were higher than those in control group (P<0.01). 3. The levels of vWF and Endocan in the three PSVT subgroups were increased gradually during the disease attack (P<0.05). 4. The levels of vWF and Endocan after PSVT were decreased significantly more than upon disease attack (P<0.01). Conclusion: Alcohol intake, smoking, and stress were risk factors for paroxysmal supraventricular tachycardia. VWF and Endocan concentrations were significantly increased upon PSVT attack, but greatly decreased after the disease attack while still higher than those of the control group. The concentrations of vWF and Endocan in PSVT group were increased gradually in a time course manner, which showed that these two hormones involved in the pathophysiological process of PSVT. This phenomenon may be one of homeostasis regulation functions as the body's stress compensation mechanism.

Keywords:

Paroxysmal ventricular tachycardia; Risk factors; von Willebrand Factor; Endocan

Cite the Article:

Wang Y, Feng XK, Ma GD, Jin H, Zhai Z, Li C. The Changes of von Willebrand Factor and Endocan Concentrations During and After Reversion of Paroxysmal Ventricular Tachycardia. Ann Clin Case Rep. 2023; 8: 2546..