An Ectopic Cushing’s Syndrome with Severe Psychiatric Presentation: A Case Report

Bayar I1*, Ben Amor B1, Abid S1, Abdelali M2, Majdoub W3, Sayadi H1, Marmouch H1 and Khochtali I1

1Department of Endocrinology-Internal Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia
2Department of Radiology, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia
3Department of Pathology, Sahloul University Hospital, University of Sousse, Tunisia

^*Correspondance to: Ines Bayara 

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Abstract:

Ectopic ACTH Secreting (EAS) tumor is relatively rare entity that presents with severe manifestation due to high level of endogenous hypercortisolism and rapidity of its onset. We report a case of severe EAS in a young Tunisian man resulting from a well differentiated Neuroendocrine Tumor (NET) of the lung. Besides catabolic signs and profound hypokalemia orienting towards Cushing’s Syndrome (CS), psychiatric symptoms were particularly severe, dominant and atypical including persecutory delusions, depression and anxiety. After tumor localization, successful resection was performed and the majority of psychiatric symptoms resolved rapidly except for mild depression.

Keywords:

Cushing’s syndrome; Neuroendocrine tumor; Ectopic ACTH secretion; Psychiatric presentation; Hypokalemia; Tunisia

Cite the Article:

Bayar I, Ben Amor B , Abid S, Abdelali M, Majdoub W, Sayadi H. An Ectopic Cushing’s Syndrome with Severe Psychiatric Presentation: A Case Report. Ann Clin Case Rep. 2023; 8: 2534..