Ann Clin Case Rep | Volume 8, Issue 1 | Case Report | Open Access

A Case Report of Acute Transverse Myelitis with Anti- Amphiphysin Positivity

Karabudak S1*, Uslu F1, Gürsoy AE2

1Department of Neurology, Bezmialem Vakif University Hospital, Istanbul, Turkey
2Department of Neurology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey

*Correspondance to: Saniye Karabudak 

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Transverse Myelitis (TM) is a rare, acquired spinal cord disease that may present with rapid-onset weakness, sensory changes, and bowel or bladder dysfunction. It may occur different reasons. Paraneoplastic myelopathies are one of the rare etiologies. Anti-amphiphysin positivity associated with breast cancer and Stiff-Person Syndrome in women may rarely lead to isolated TM. We report a 35-year-old case that presents with paraplegia which occurred gradually in 20 days accompanied by as sensory defect at T8 level. MRI showed multiple peripheral hyperintensities localized at cervical and lower thoracic levels, with millimetric contrast enhancement along with anti-amphiphysin positive results from paraneoplastic antibodies after IVMP and plasmapheresis treatment with maintenance oral prednisolone.


Karabudak S, Uslu F, Gürsoy AE. A Case Report of Acute Transverse Myelitis with Anti-Amphiphysin Positivity. Ann Clin Case Rep. 2023; 8: 2409.

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