An Adult Case Diagnosed with Group B Streptococcal Meningitis Using Metagenomic Next-Generation Sequencing

Deng J, Zhu H, Chen X, Chen Y, Liu M, Yu X* and Chen P*

Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, China

^*Correspondance to: Xuegao Yu 

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Abstract:

Group B Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden of GBS infections among nonpregnant adults, particularly older adults and those with underlying medical conditions. Although GBS meningitis is frequently rapidly progressive with a high fatality rate, it can be difficult to diagnose. We present a 77-year-old male who was highly suspected of bacterial meningitis with negative Cerebrospinal Fluid (CSF) cultures. GBS meningitis was diagnosed by positive result from metagenomic Next- Generation Sequencing (mNGS) of CSF. The patient made a rapid clinical improvement, likely attributable to the fact that empiric antibiotic treatment was started soon after his admission, which provided the broad coverage and included non-resistant GBS coverage.

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Cite the Article:

Deng J, Zhu H, Chen X, Chen Y, Liu M, Yu X, et al. An Adult Case Diagnosed with Group B Streptococcal Meningitis Using Metagenomic Next-Generation Sequencing. Ann Clin Case Rep. 2022; 7: 2345.