Recurrent Optic Neuritis as the First Presentation of Monoclonal Gammopathy of Undetermined Significance (MGUS): A Case Report

Ahmad Pourmohammadi1,2, Saba Naghavi1,3 and Iman Adibi1,3*

1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran
3Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

^*Correspondance to: Iman Adibi 

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Abstract:

Monoclonal Gammopathy of Undetermined Significance (MGUS), which can be asymptomatic, is a premalignant proliferative disorder of plasma cells. The peripheral nervous system may be involved in MGUS, causing a monoclonal gammopathy associated peripheral neuropathy. However, involvement of the Central Nervous System (CNS) in MGUS was rarely reported. Here we report a rare case of recurrent optic neuritis, as the first clinical presentation of MGUS, in an otherwise healthy male patient. He was treated with intravenous high-dose methylprednisolone for acute attacks and Rituximab as maintenance therapy. The patient’s vision was recovered, and he did not experience any other attack in one year of follow-up.

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Cite the Article:

Pourmohammadi A, Naghavi S, Adibi I. Recurrent Optic Neuritis as the First Presentation of Monoclonal Gammopathy of Undetermined Significance (MGUS): A Case Report. Ann Clin Case Rep. 2022; 7: 2304..