Thymic Large-Cell Neuroendocrine Carcinoma: A Case Report and Review of a Japanese Case Series

Mariko Takishita, Hisashi Saji, Hideki Marushima, Tomoyuki Miyazawa, Hiroyuki Kimura, Hiroki Sakai, Yoichi Wakiyama, Masataka Tsuda, Koji Kojima, Masahiro Hoshikawa, Masatomo Doi, Masayuki Takagi and Haruhiko Nakamura

Department of Chest Surgery, St. Marianna University School of Medicine, Japan
Department of Pathology, St. Marianna University School of Medicine, Japan
Department of Thoracic Surgery, Tokyo Medical University, Japan

^*Correspondance to: Hisashi Saji 

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Abstract:

Large-Cell Neuroendocrine Carcinoma (LCNEC) of the thymus is a rare, aggressive cancer that leads to a poorer prognosis than other thymic epithelial tumors. A 54 year old Chinese male presented with an anterior Mediastinal mass as per chest computed tomography findings. Histological examination after thymothymectomy revealed primary thymic LCNEC. We reviewed 40 cases of this rare cancer that have been reported in Japan. To our knowledge, even though thymic LCNEC is sub classified as part of the thymic NEC group in accordance with the classification of pulmonary neuroendocrine tumors, the detailed clinical features and therapeutic management remain unknown.

Keywords:

Large-cell neuroendocrine carcinoma; Thymic cancer; Prognosis

Cite the Article:

Takishita M, Saji H, Marushima H, Miyazawa T, Kimura H, Sakai H, et al. Thymic Large-Cell Neuroendocrine Carcinoma: A Case Report and Review of a Japanese Case Series. Ann Clin Case Rep. 2018; 3: 1542.