Ulcerative Colitis Associated with Cholangiocellular Carcinoma: A Case Report and Literature Review

Lei Li, Ying Fang, Ruofan Sheng, Yujen Tseng, Xizhong Shen and Jiyao Wang

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

^*Correspondance to: Jiyao Wang 

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Abstract:

A 24-year-old female patient has a history of Ulcerative colitis (UC) for 14 years and was treated with mesalazine. Her UC symptoms were alleviated after administration of mesalazine, however, she was repeatedly found to have abnormal liver function. The diagnosis of Cholangiocellular Carcinoma (CCC) was made via ultrasound and magnetic resonance imaging. Clinical data of the patient was retrospectively analyzed and relevant literature was reviewed to investigate the possibility for Ulcerative Colitis (UC) to progress to Cholangiocellular Carcinoma (CCC). A review of the literature suggested that UC is commonly associated with concomitant primary sclerosing cholangitis, which progresses to CCC in 11% of cases. Clinicians should be aware that UC may progress to CCC. UC patients with recurrent abnormal liver function, especially in those with serum alkaline phosphatase elevation, should undergo relevant examinations to clarify diagnosis.

Keywords:

Ulcerative colitis; Primary sclerosing cholangitis; Cholangiocellular carcinoma

Cite the Article:

Li L, Fang Y, Sheng R, Tseng Y, Shen X, Wang J. Ulcerative Colitis Associated with Cholangiocellular Carcinoma: A Case Report and Literature Review. Ann Clin Case Rep. 2017; 2: 1351.