A Case Report on Recurrent Oral Ulcers Associated with Cyclic Neutropenia

Yao Liu, Jie Fu, Jie Zhang, Ying Wang and Xiaobing Guan

Department of Oral Medicine, Capital Medical University, Beijing, China
These authors contributed equally to this work

^*Correspondance to: Xiaobing Guan 

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Abstract:

A 12-year-old boy had recurrent oral ulcer and gingival necrosis accompanied with fever, pharyngalgia and painful neck lymph nodes since six months of age. Laboratory examinations revealed an oscillation of peripheral blood neutrophils from normal to severely low levels, with 21-day periodicity. A mutation in exon 4 of neutrophil elastase 2 (ELA2) was identified. The symptoms and lab examination led to the diagnosis of cyclic neutropenia. After the patient received recombinant human granulocyte colony-stimulating factor (rhG-CSF) treatment around the early neutropenic phase, the symptoms abated and peripheral blood neutrophil counts returned to normal levels. This case demonstrates the need for oral medicine clinicians to perform testing for cyclic neutropenia when patients are afflicted with recurrent oral ulcers.

Keywords:

Oral ulcer; Cyclic neutropenia; Neutrophil elastase 2

Cite the Article:

Liu Y, Fu J, Zhang J, Wang Y, Guan X. A Case Report on Recurrent Oral Ulcers Associated with Cyclic Neutropenia. Ann Clin Case Rep. 2017; 2: 1314.