Dilated Cardiomyopathy in a 25-Year-Old Patient as a Result of Radiation and Chemotherapy after Stem Cell Transplantation

Raluca Diosteanu, Gerhard Schuler and Hilka Gunold

Department of Internal Medicine and Cardiology, University Leipzig, Germany

^*Correspondance to: Raluca Diosteanu 

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Abstract:

Dilated cardiomyopathy is a disorder characterized by chamber dilatation and cardiac dysfunction, which is not the result of an ischemic or valvular heart disease. The authors report the occurrence of dilated cardiomyopathy in an asymptomatic 25-year-old patient with a history of chemotherapy (Fludarabine and ATG- antithymocyte globuline) and radiation therapy prior to stem-cell transplantation for septic granulomatosis, which was diagnosed 10 years after transplantation. This proved to be refractory to the initiated medication and made the implantation of a CRT-D (cardiac resynchronization with defibrillation therapy) device necessary. The long-term outcome especially in young patients is unknown and the need for assist device or heart transplantation should be closely evaluated in case of further worsening of the cardiac function.

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Cite the Article:

Diosteanu R, Schuler G, Gunold H. Dilated Cardiomyopathy in a 25-Year- Old Patient as a Result of Radiation and Chemotherapy after Stem Cell Transplantation. Ann Clin Case Rep. 2016; 1: 1202.