Journal Basic Info

  • Impact Factor: 1.809**
  • H-Index: 6
  • ISSN: 2474-1655
  • DOI: 10.25107/2474-1655
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Pathology
  •  Anesthesiology and Pain Medicine
  •  Allergy & Immunology
  •  Anatomy
  •  Women’s Health Care
  •  Epidemiology
  •  Asthma
  •  Internal Medicine


Citation: Ann Clin Case Rep. 2016;1(1):1107.DOI: 10.25107/2474-1655.1107

Müllerian Tumor Originating from the Pleura in a 47-Years Old Woman: A Case Report

Alice Baldi, Martina Mandarano, Daniela Zicari, Biagio Ricciuti, Rita Chiari, Giulio Metro, Stefania Gori, Giulia Costanza Leonardi, Luca Paglialunga, Angelo Sidoni and Lucio Crinò

Department of Medical Oncology, Azienda Ospedaliera di Perugia, Italy
Department of Experimental Medicine - Section of Anatomic Pathology and Histology, Medical School, University of Perugia, Italy Department of Medical Oncology, Ospedale Sacro Cuore, Italy

*Correspondance to: Alice Baldi 

 PDF  Full Text Case Report | Open Access


Introduction: Malignant müllerian tumors usually originate from the female genital tract as mϋllerian ducts develop during embryogenesis to form fallopian tubes, uterus and the upper third of the vagina. An extragenital origination occurs infrequently, but it has been mainly described in the peritoneum or retroperitoneum.Case
Presentation: We report the case of a 47-years old woman presented with thoracic pain progressively worsening and cough. A chest CT revealed right pleural effusion and a paramediastinic nodule. She underwent a video-assisted-toracoscopy with pleural biopsies. The immunohistochemical profile observed, particularly the positivity for WT-1 and PAX-8, together with the negativity of other lineage-specific markers allowed us to lead to the diagnosis of Primary Müllerian tumor of the pleura.
Discussion: PAX8 is a very useful marker for diagnosing carcinomas of müllerian origin. Besides, our patient received chemotherapy with carboplatin-paclitaxel and bevacizumab followed by bevacizumab maintenance, achieving a long lasting stable disease. To our knowledge, this is the second case of primary pleural müllerian tumor up to now report in the literature.


Extra-genital müllerian tumors; PAX-8; Pleura; WT-1

Cite the Article:

Baldi A, Mandarano M, Zicari D, Ricciuti B, Chiari R, Metro G, et al. M�llerian Tumor Originating from the Pleura in a 47-Years Old Woman: A Case Report. Ann Clin Case Rep. 2016; 1: 1107.

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