Unusual Presentation of Hodgkin Lymphoma with Limbic Encephalitis (Ophelia Syndrome)

Ramachandran P and O’Brien T

Department of Hematology/Oncology, Metrohealth Medical Center, USA

^*Correspondance to: Ramachandran P 

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Abstract:

Introduction: Hodgkin lymphoma is a potentially curable lymphoma which has unique biological, clinical and histological characteristics. It is associated with multiple paraneoplastic neurological syndromes of which limbic encephalitis is a very rare presentation. Antibody against mGLUR5 seems to be associated for this presentation.Case
Presentation: Here we describe a rare case of a 60 year old Caucasian lady newly diagnosed with stage 4B Hodgkin lymphoma who presented with progressive neurological deterioration. Timely decision to treat her underlying malignancy with chemotherapy resulted in are markable recovery in her neurological status within few weeks of treatment.Conclusion: This case emphasis the need to investigate for paraneoplastic disorders when patients with Hodgkin lymphoma presents with neurological changes. Sometimes it may be the only presentation of the underlying tumor which poses a diagnostic challenge to the physicians. Early treatment of the underlying tumor helps in successful neurological recovery.

Keywords:

Ophelia syndrome; Limbic encephalitis; Hodgkin lymphoma

Cite the Article:

Ramachandran P, O′Brien T. Unusual Presentation of Hodgkin Lymphoma with Limbic Encephalitis (Ophelia Syndrome). Ann Clin Case Rep. 2016; 1: 1047.