Terlipressin-Induced Irreversible Severe Skin Necrosis: A Dreadful Complication

Cleva RD, Santarém OLDA and Herman P

Department of Gastroenterology, University of São Paulo Medical School, Brazil

^*Correspondance to: Paulo Herman 

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Abstract:

Terlipressin (triglycyl lysine vasopressin), a synthetic analogue of vasopressin, has been employed in the last years for the treatment of upper digestive bleding from esophagogastric varices and for hepatorenal syndrome. Several adverse effects have been reported, all reversible after dose reduction or drug interruption. The authors report two rare cases of irreversible severe skin necrosis induced by terlipressin infusion.

Keywords:

Terlipressin; Portal hypertension; Digestive bleeding; Hepatorenal syndrome

Cite the Article:

Cleva RD, Santarém OLDA, Herman P. Terlipressin-Induced Irreversible Severe Skin Necrosis: A Dreadful Complication. Ann Clin Case Rep. 2016; 1: 1040.