Successful Pregnancy Following Sub-Endometrial PRP Injection in a Patient with Thin Endometrium: A Case Report

Shubham Bidhuri, Mekhala Iyenger, Shyam Gupta, Reenu Kawar, Vipin Chandra and Shashank Sanagoudar

Indira IVF Hospital Limited, Bangalore, India Indira IVF Hospital Limited, Udaipur, India

^*Correspondance to: Shashank Sanagoudar 

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Abstract:

Thin endometrium poses a significant barrier to successful embryo implantation in assisted reproductive technology. This report describes a 36-year-old woman with primary infertility, diminished ovarian reserve, and persistent thin endometrium (≤6.8 mm despite hormonal priming), who achieved a successful term pregnancy after hysteroscopy-guided sub-endometrial platelet-rich plasma (PRP) injection combined with adhesiolysis. Following ovarian stimulation, preimplantation genetic testing, and frozen euploid blastocyst transfer in a hormone replacement cycle, serum β-hCG confirmed pregnancy at 1615 mIU/mL on day 14 post-transfer, culminating in a healthy term delivery. This case highlights PRP's potential to enhance endometrial receptivity in cases of refractory infertility.

Keywords:

Thin endometrium, Platelet-rich plasma, IVF, Embryo transfer, Infertility

Cite the Article:

Bidhuri S, Iyenger M, Gupta S, Kawar R, Chandra V, Sanagoudar S. Successful Pregnancy Following Sub- Endometrial PRP Injection in a Patient with Thin Endometrium: A Case Report. Ann Clin Case Rep. 2026; 11: 2848..