Trimèche-Othmani T1, Vodovar N4, Callebert J2, Maatouk F3, Launay JM2, Mebazaa A4,5 and Kenani A1*
1UR12ES08- University of Monastir, Tunisia
2Department of Biochemistry, Lariboisière Hospital, Paris, France
3Department of Cardiology, Fattouma Bourguiba Hospital, Tunisia
4Inserm UMR-S 942, France
5Department of Anesthesiology and Intensive Care, Lariboisière Hospital, France
Background: Galectin-3 (Gal-3), as a mediator of inflammation and fibrosis, has been reported to be a biomarker of severity in Coronary Artery Disease (CAD). However, the relationship between oxidative stress and Gal-3 in CAD is less clear. The study aimed to assess the relationships between Coronary Artery Disease (CAD) and risk factors, including parameters of oxidative stress and inflammation, in Tunisian patients with stable and unstable CAD. Aims: The goal of this study was to examine the relationships between Coronary Artery Disease (CAD) and risk factors, including oxidative stress parameters and galectin-3as an inflammation marker, in Tunisian patients with stable and unstable CAD. Methods: The study enrolled 257 patients affected by CAD. Serum Gal-3 was measured using ELISA, stress oxidative parameters were assayed in erythrocytes, and assessed the presence of CAD by coronary angiography and the severity of coronary atherosclerosis with the Gensini score. Results and Conclusion: Unstable patients had a higher plasma Galectin-3 level in comparison to the stable subjects. We hypothesize that Gal-3 could be a useful biomarker of atherosclerotic plaque and in particular of its destabilization. We conclude that oxidative stress could be an important supplemental parameter to predict CAD.
Trimèche-Othmani T, Vodovar N, Callebert J, Maatouk F, Launay JM, Mebazaa A, et al. Association between Galectin-3 and Oxidative Stress Parameters with Coronary Artery Disease in Tunisian Population. Ann Clin Case Rep. 2022; 7: 2324..