Abdoulaye Condé1*, Saint-Cyr Packo2, Aboubacar Sidiki Doukouré1, Mamady Diakité3, M Epoh1, RP Botti1, AE Mankpi1, KMC Womey1, D Ruth1, Clotaire Danho Nanho1 and Aissata Tolo1
1Department of Clinical Hematology, Yopougon University Hospital, Côte d'Ivoire 2Department of Clinical Hematology, Le Mans Hospital Center, France 3Department of Hematology, Ignace Deen National Hospital, Conakry University Hospital, GuineaFulltext PDF
Background: Biermer's disease is an autoimmune disorder, characterized by vitamin B12 malabsorption with the presence of atrophic gastropathy and various autoantibodies including antibodies to intrinsic factor. It is mainly described in Caucasian subjects in their sixties. However, it also exists in black African subjects, but occurs at a younger age. It is easily diagnosed by the association of vitamin deficiency and macrocytosis. However, various circumstances may mask the macrocytosis and thus complicate the diagnosis. The authors report the case of a patient presenting with normocytic normochromic anemia because of its rarity. Case Report: The patient was 48 years old and was referred to a hematology consultation for investigation and etiology of a normocytic anemia of chronic evolution (Hb=8.5 g/dl, VGM=92fl, TCMH=32Pg). The diagnosis of Biermer's disease was made on the basis of the criteria of chronic anemia of insidious evolution, medullary megaloblastosis, serum vitamin B12 deficiency and the positivity of the anti-intrinsic factor antibody test. Conclusion: This observation reminds us that a normocytic anemia does not exclude the diagnosis of vitamin B12 deficiency.
Biermer's disease; Normocytic anemia; Vitamin B12
Condé A, Packo S-C, Doukouré AS, Diakité M, Epoh M, Botti RP. Biermer's Disease Revealed by Normocytic Normochromic Anemia: A Case Report from the Clinical Hematology Department of Yopougon. Ann Clin Case Rep. 2022; 7: 2220..