Diagnostic Dilemma: A Presentation of Chest Pain in a Patient with Ehlers-Danlos and Klinefelter Syndromes

Christopher D. Louviere, MD*, Param P. Patel, Maxwell V. Dacquel, DO, and Morgan E. Wright, MD

Memorial University Medical Center, Savannah, GA Mercer University School of Medicine, Savannah, GA

^*Correspondance to: Christopher D. Louviere 

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Abstract:

We describe a young man with Ehlers-Danlos syndrome and Klinefelter syndrome who presented with acute chest pain, syncope, and transient bilateral weakness, and underwent urgent evaluation for life-threatening vascular and neurologic processes. His heritable connective tissue and endocrine disorders heightened the physiologic risk of disease and diagnostic concern. Following comprehensive exclusion of existing pathology, the acute presentation was attributed to functional neurologic disorder, arising from the interaction of psychological stressors and neurobiological dysfunction. This case report highlights how complex medical histories can both complicate and warrant exhaustive evaluation, while also contributing to functional and symptomatic presentations.

Keywords:

Chest Pain

Cite the Article:

Louviere CD, Patel PP, Dacquel MV, Wright ME. Diagnostic Dilemma: A Presentation of Chest Pain in a Patient with Ehlers-Danlos and Klinefelter Syndromes. Ann Clin Case Rep. 2026; 11: 2813..