Incidental Discovery of a Rare Hemoglobin Variant (Hb G-Siriraj) in a Moroccan Patient During HbA1c Measurement by Capillary Technique

W. Rifi*, T. Benlamkaddem, Y. Eddair, A. Biaz, S. Bouhsain, A. Dami and S. Elmachtani Idrissi

Department of Biochemistry-Toxicology, Mohammed V Military Hospital, Rabat, Morocco

^*Correspondance to: Wafae Rifi 

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Abstract:

Background: Hemoglobin G-Siriraj is a rare hemoglobin variant resulting from a point mutation in the β-globin gene (HBB: c.22G>A), generally asymptomatic in its heterozygous state. We report here the second suspected case identified in Morocco, discovered incidentally during routine HbA1c testing using capillary electrophoresis. Methods: The variant was identified in a 58-year-old Moroccan patient undergoing biological follow-up for cardiovascular risk. An abnormal peak was observed during HbA1c measurement on the Capillarys OCTA 3 Sebia® analyzer. Additional investigations using high-performance liquid chromatography (ARKRAY), alkaline capillary electrophoresis, and acid agarose electrophoresis suggested the presence of Hb G-Siriraj. The HbA1c result was not affected by the variant, allowing a reliable interpretation. Definitive diagnosis requires molecular analysis of the HBB gene. Conclusion: This case illustrates the analytical contribution of modern diagnostic platforms in identifying rare hemoglobin variants. It emphasizes the importance of integrating multiple analytical techniques and post-analytical interpretation to ensure accurate diagnosis and result validation.

Keywords:

Hemoglobinopathy; Capillary electrophoresis; Hb G-Siriraj; HbA1c

Cite the Article:

Rifi W, Benlamkaddem T, Eddair Y, Biaz A, Bouhsain S, Dami A, et al. Incidental Discovery of a Rare Hemoglobin Variant (Hb G-Siriraj) in a Moroccan Patient During HbA1c Measurement by Capillary Technique. Ann Clin Case Rep. 2025; 10: 2805..