A Rare Pediatric Cluster of Acute Inflammatory Demyelinating Polyneuropathy: Familial Occurrence in Three Siblings

Kylie Wu*, Nikhil Crain, Talon Aitken, Mark Brittan and Jason Zamkoff

Department of Pediatrics, Children’s Hospital Colorado, Aurora, CO, USA Department of Family Medicine, HCA HealthONE Swedish, Engelwood, CO, USA

^*Correspondance to: Kylie Wu 

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Abstract:

Acute Inflammatory Demyelinating Polyneuropathy (AIDP), the most common subtype of Guillain- Barré Syndrome (GBS), typically occurs sporadically, and familial clustering is rarely reported, particularly among children. This report describes three pediatric patients, two sisters aged 9 and 10, and their 18-year-old half-brother with shared maternal lineage, all diagnosed with AIDP within 18 months. Presentations included progressive lower extremity weakness, sensory changes, and diminished reflexes. Diagnostic evaluation incorporated cerebrospinal fluid analysis, neuroimaging, and antibody testing. Each patient demonstrated clinical improvement after treatment; however, one required readmission for recurrent symptoms. Though familial susceptibility to GBS has been explored in prior studies, the precise influence of genetic predisposition and potential impact on subsequent generations within a family is still not well understood. This report highlights the unusual occurrence of multiple family members with AIDP at relatively young ages, adding to the limited literature on early-onset familial cases and underscoring the need for further investigation.

Keywords:

Guillain- Barré Syndrome

Cite the Article:

Wu K, Crain N, Aitken T, Brittan M, Zamkoff J. A Rare Pediatric Cluster of Acute Inflammatory Demyelinating Polyneuropathy: Familial Occurrence in Three Siblings. Ann Clin Case Rep. 2025; 10: 2780..