Positive Impact of High-Frequency Hydroxocobalamin Administration on the Exercise Capacity in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy

Auwerda JJA* and Ellis EL

Bijlmerdreef 1169-4, 1103 TT Amsterdam, Netherlands

^*Correspondance to: JJA Auwerda 

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Abstract:

Hydroxocobalamin is used to treat patients with symptomatic vitamin B12 deficiency. The British National Formulary recommends initiating treatment with alternate-day intramuscular (i.m.) administration of 1000 mcg hydroxocobalamin, maintaining this regimen until all symptoms have resolved or no longer improve. A subset of patients with B12 deficiency requires high-frequency i.m. supplementation to remain symptom-free, but the mechanism behind this need is clarification. We describe a patient who showed maximum improvement in symptoms and exercise capacity only with daily administration. Reducing the injection frequency worsened symptoms and objectively decreased exercise capacity. More research is needed to elucidate why some patients with symptomatic B12 deficiency require high frequency i.m. supplementation and to determine the best individualized regimen for such individuals.

Keywords:

B12 deficiency

Cite the Article:

Auwerda JJA, Ellis EL. Positive Impact of High-Frequency Hydroxocobalamin Administration on the Exercise Capacity in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy. Ann Clin Case Rep. 2025; 10: 2740..