Discordant Congenital Cytomegalovirus Infection in Dichorionic Diamniotic Twins—A Case Report

Chiara Tricella*, Benedetta Panero, Barbara Caruselli, Alice Proto, Marco Fossati, Francesca De Rienzo and Stefano Martinelli

Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

^*Correspondance to: Chiara Tricella 

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Abstract:

Congenital cytomegalovirus (CMV) infection is the most common congenital infection, affecting 0.5% to 2% of live births and leading significantly to neurodevelopmental disabilities. Transmission rates are highest following primary maternal infection, with 10-15% of affected infants exhibiting symptoms at birth, while others may develop long-term sequelae. This case report describes a dichorionic diamniotic twin pregnancy complicated by maternal CMV seroconversion during the first trimester. The mother received antiviral treatment and underwent close monitoring, with ultrasounds showing no abnormalities. At 38 weeks, the twins were delivered via cesarean section. The first twin tested positive for CMV but remained asymptomatic, while the second twin tested negative and showed no signs of infection. Both were discharged in good health and followed up without complications. This case highlights the complexities of managing congenital CMV in twin pregnancies, where infection status may differ between twins. A multidisciplinary approach, early diagnosis, and appropriate treatment are essential to optimize outcomes. Further research is needed to better understand CMV transmission in twin pregnancies and to develop effective preventive strategies.

Keywords:

Congenital cytomegalovirus

Cite the Article:

Tricella C, Panero B, Caruselli B, Proto A, Fossati M, De Rienzo F, et al. Discordant Congenital Cytomegalovirus Infection in Dichorionic Diamniotic Twins—A Case Report. Ann Clin Case Rep. 2025; 10: 2734..