Progression from Chronic Myeloid Leukemia to Chronic Lymphocytic Leukemia: A Rare Case

Aytan Shirinova, Zohra Alimirzoyeva, Salik Agamuradov and Chingiz Asadov

Department of Haematology, National Hematology and Blood Transfusion Center, Azerbaijan

^*Correspondance to: Aytan Shirinova 

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Abstract:

Background: The occurrence of myeloproliferative and lymphoproliferative diseases in the same individual is rare. However, such cases are described in the literature. CLL and CML co-occurrence in one patient develops in 3 forms - two diseases at the same time, CLL after the diagnosis of CML, or vice versa CML after the diagnosis of CLL. Case Report: 52 years old male Caucasian patient presented with nose bleeding, fatigue, fever, ascites. CML was considered and was done all necessary tests. CBC, bone marrow aspiration and FISH analysis showed significant results with CML. Ph chromosome was positive in all metaphases. Imatinib 400 mg was prescribed to the patient and after 12 months he achieved MMR. After 11 years CBC showed leukocytosis so imatinib dosage elevated to 600 mg and PCR monitoring for MMR was performed. The patient did not lose MMR but leukocytosis dynamically elevated, so we decided to perform bone marrow trephine-biopsy. Result: Lymphocytosis. Flow cytometry results: CD19+, CD20+, CD22+, CD5+,CD10-, CD23+, CD43+, CD56-, FMC7-, CD200+, CD11c-, CD103- CLL diagnosis verified and chlorambucil 4 mg was prescribed. Conclusions: Although it is uncommon, physicians must consider CLL in the spectrum of CML progression along with more common secondary neoplasms such as solid tumors or lymphomas.

Keywords:

Coexisting CLL/CML; Chronic lymphocytic leukemia; Chronic myeloid leukemia

Cite the Article:

Shirinova A, Alimirzoyeva Z, Agamuradov S, Asadov C. Progression from Chronic Myeloid Leukemia to Chronic Lymphocytic Leukemia: A Rare Case. Ann Clin Case Rep. 2024;9:2692..