Correlation between Body Mass Index and Perianal Abscess Hazards: A Mendelian Randomization Investigation

Saad HA1*, Farid MI1, Eraky ME1, El-Taher AK1, Sharaf K1, Baz A2 and Riad M2

1Department of Surgical, Zagazig University, Egypt
2Department of Surgical, Alahrar Teaching Hospital, Egypt

^*Correspondance to: Hassan A Saad 

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Abstract:

Background: Perianal abscess is an infectious disease that frequently impacts the perianal area. For assessing weight and weight gain, body mass index, or BMI, is a commonly used statistic. Although there is evidence linking obesity to several medical conditions, the relationship between BMI and perianal abscess remains unclear. Whether BMI influences the likelihood of a perianal abscess remains under discussion. Methods: A two-sample Mendelian Randomization (MR) study was conducted using the weighted average, weighting the median, Weighted Inverse-Variance Weighted (IVW), and MR-Egger regress approaches. Using the accessible to everybody summarized collections of GWAS meta-analyses for BMI among people of South Asian descent (n=8,658) as the being exposed, a Genome-Wide Association Experiment (GWAS) for anal and rectal abscess from people who are involved in the Open GWAS database (total n=183710; case=1 287, control =182423) was applied as the outcome. Results: We used GWASs to find 29 Single Nucleotide Polymorphisms (SNPs) of genome-wide relevance, using BMI as the variable in question. The IVW technique indicates that there is not enough information to determine a cause-and-effect link among BMI and perianal abscess (Beta= -0.093, SE=0.097, P=0.340). An analysis of MR-Egger regression revealed a lack of causality among BMI and perianal abscess (Beta= -0.254, SE=0.177, P=0.162). The analysis also showed that directed multiplication was improbable to be influencing the results (intercept = 0.024; P=0.285). Furthermore, there is no proof that a link involving BMI and perianal abscess exists according to the weighted mean (Beta= -0.207, SE=0.182, P=0.813) or weighted median (Beta= -0.126, SE=0.139, P=0.363). The funnel plot and the Cochran's Q test, which also revealed no evidence of diversity or imbalances, demonstrated that there had been no direction pleiotropy. In summary, there was insufficient data from the MR the outcomes of analysis to substantiate the theory linking a greater BMI with a higher incidence of perianal abscess.

Keywords:

BMI; Perianal abscess; Mendelian randomization

Cite the Article:

Saad HA, Farid MI, Eraky ME, El-Taher AK, Sharaf K, Baz A, et al. Correlation between Body Mass Index and Perianal Abscess Hazards: A Mendelian Randomization Investigation. Ann Clin Case Rep. 2023; 8: 2516.