Platelet-to-Portal Vein Width Ratio and Platelet-to-Spleen Thickness Ratio can be Used to Predict Advanced Liver Fibrosis Among Patients with HBV Infection with HBeAg- Negativity and a Normal ALT Level

Mudan Feng1,2#, Lan Lei2#, Yuzhi Shi3, Wenfeng Yang3 and Jian Xu3*

1Department of Infectious Disease, Affiliated Hospital of North Sichuan Medical College, China 2Department of Hepatology & Translation Medicine, Fuling Center Hospital of Chongqing City, China 3Department of Infectious Disease, The People’s Hospital of Yubei District of Chongqing City, China #These authors contributed equally to this work

^*Correspondance to: Jian Xu 

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Abstract:

Background: People infected with the Hepatitis B Virus (HBV) with a normal level of Alanine Aminotransferase (ALT) are at risk of disease progression. We evaluated the value of Platelet-to-Portal vein Width Ratio (PPR) and Platelet-to-Spleen Thickness Ratio (PSR) to predict advanced liver fibrosis among patients with HBV infection with HBV e Antigen (HBeAg)-negativity and a
normal ALT level.
Design and Methods: HBV surface Antigen (HBsAg) -positive and HBeAg-negative individuals with a normal ALT level was enrolled. The inflammation Grade (G) and fibrosis Stage (S) wereanalyzed according to pathological features. Two groups (<S2 vs. ≥ S2) were divided based on the pathological diagnosis, and the clinical characteristics were summarized.
Results: 73 individuals among 142 patients had a normal ALT. 83.56% (61/73) individual's showed advanced liver fibrosis (≥ S2). The level of ALT between the two groups differed (21.01 ± 7.40 vs. 25.37 ± 7.90 U/L, p=0.08). Platelet count, PPR, and PSR were significantly different between the two groups ((145.92 ± 14.55) × 109/L vs. (126.38 ± 23.85) × 109/L, p=0.008; 10.80 ± 1.30 vs. 9.01 ± 1.97, p=0.004; 4.21 ± 0.65 vs. 3.33 ± 0.89, p=0.02, respectively). The PPR and PSR decreased gradually upon fibrosis aggravation (p<0.05).
Conclusion: The PPR and PSR can be employed to assess fibrosis progression among patients with HBV infection with HBeAg-negativity and a normal ALT.

Keywords:

Fibrosis stage; Hepatitis B virus; Normal ALT; Platelet-to-portal vein width ratio; Platelet-to-spleen thickness ratio

Cite the Article:

Feng M, Lei L, Shi Y, Yang W, Xu J. Platelet-to-Portal Vein Width Ratio and Platelet-to-Spleen Thickness Ratio can be Used to Predict Advanced Liver Fibrosis Among Patients with HBV Infection with HBeAg-Negativity and a Normal ALT Level. Ann Clin Case Rep. 2022; 7: 2125..