Omega-3 Polyunsaturated Fatty Acids Improved Cholestasis in Biliary Atresia after the Kasai Operation

Ji Yeon Han1, Aram Kwon1 and Sun Hwan Bae1,2*

1Department of Pediatrics, Konkuk University Medical Center, South Korea 2Konkuk University School of Medicine, South Korea

^*Correspondance to: Sun Hwan Bae 

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Abstract:

Biliary atresia is a progressive fibro-inflammatory disease of the extrahepatic biliary tree that presents with biliary obstruction. An 8-week-old female infant was admitted our hospital due to jaundice and acholic stool. She has been jaundiced since two days after birth; her stool was acholic since she was 6 weeks of age. She was diagnosed biliary atresia; the Kasai operation was performed. However, after operation, her clinical symptoms and biochemical parameters got worse despite being on usual supportive therapy, including ursodeoxycholic acid. An oral omega-3 polyunsaturated fatty acids agent was started on day-77 after the operation. After this treatment, her clinical symptoms and biochemical parameters, including bilirubin and aminotransferase, improved. We report that omega-3 polyunsaturated fatty acids might work as a potent choleretic agent in infants with biliary atresia after Kasai operation.

Keywords:

Omega-3 fatty acids; Biliary atresia; Cholestasis

Cite the Article:

Han JY, Kwon A, Bae SH. Omega-3 Polyunsaturated Fatty Acids Improved Cholestasis in Biliary Atresia after the Kasai Operation. Ann Clin Case Rep. 2021; 6: 2037..